Title : Inhibition of interleukin-12 expression in diltiazem-treated dendritic cells through the reduction of nuclear factor-kappa B transcriptional activity.

Pub. Date : 2005 Feb 1

PMID : 15652234






2 Functional Relationships(s)
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1 On the other hand, the subcellular distribution of NF-kappa B subunits was clearly affected in diltiazem-treated DCs following LPS stimulation, with a reduced nuclear translocation of p65, and RelB, and a nuclear accumulation of p50 subunit. Diltiazem RELA proto-oncogene, NF-kB subunit Homo sapiens
2 Thus, all together, our data provided evidence that in addition to the inhibition of p65/p50 nuclear translocation, the selective induction and translocation of p50/p50 homodimers is an important mechanism by which diltiazem inhibits NF-kappa B activity, and in turn, IL-12 expression. Diltiazem RELA proto-oncogene, NF-kB subunit Homo sapiens