Title : [Isaacs' syndrome, stiff person syndrome and Satoyoshi disease: pathomechanisms and treatment].

Pub. Date : 2004 Nov

PMID : 15651297






3 Functional Relationships(s)
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Protein Name
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1 Stiff person syndrome (SPS) and its variants show characteristic symptoms and signs of central nervous system hyperexcitability due to antibodies to the GABA-ergic system such as glutamic acid decarboxylase (GAD), amphiphysin 1 and gephyrin. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens
2 Stiff person syndrome (SPS) and its variants show characteristic symptoms and signs of central nervous system hyperexcitability due to antibodies to the GABA-ergic system such as glutamic acid decarboxylase (GAD), amphiphysin 1 and gephyrin. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens
3 The role of GAD is the subject of debate, however, recent studies reveal the intrathecal synthesis of GAD which is specific for SPS and appears to impair GABA synthesis. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens