Title : The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion.

Pub. Date : 2005 May

PMID : 15650019






2 Functional Relationships(s)
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1 Some steroids/EDCs strongly activated PXR-mediated transcription through the CYP3A4-responsive element compared with the MDR1-responsive element, whereas these steroids/EDCs also enhanced the CYP3A4 expression compared with the MDR1 expression. Steroids nuclear receptor subfamily 1 group I member 2 Homo sapiens
2 Some steroids/EDCs strongly activated PXR-mediated transcription through the CYP3A4-responsive element compared with the MDR1-responsive element, whereas these steroids/EDCs also enhanced the CYP3A4 expression compared with the MDR1 expression. Steroids nuclear receptor subfamily 1 group I member 2 Homo sapiens