Title : The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cells.

Pub. Date : 2005

PMID : 15647510






2 Functional Relationships(s)
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1 The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cells. Methyl Methanesulfonate DNA polymerase beta Homo sapiens
2 When replicating Pol beta null cells are treated with MMS, a rapid phosphorylation of histone H2AX is detected in the nuclei of S phase cells, indicating that double strand breaks (DSB) are formed in response to unrepaired SSB. Methyl Methanesulfonate DNA polymerase beta Homo sapiens