Title : In vivo endothelial interaction between ACE and COX inhibitors.

Pub. Date : 2005 Feb

PMID : 15626595






2 Functional Relationships(s)
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1 Intravenous injections of ACE-Is, i.e. perindopril or quinapril at non-hypotensive doses of 3-30 microg kg(-1) produced a dose-dependent thrombolysis that was associated with a parallel rise in arterial blood levels of 6-keto-PGF(1 alpha), but not those of TXB(2) or PGE(2). Quinapril angiotensin I converting enzyme Rattus norvegicus
2 Summing up, in our in vivo bioassay system ACE-Is such as quinapril, perindopril or captopril at non-hypotensive doses evoke THR that is mediated by endogenous bradykinin and prostacyclin derived from endothelial COX-2. Quinapril angiotensin I converting enzyme Rattus norvegicus