Title : Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs.

Pub. Date : 2004 Nov

PMID : 15624308






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs. Sulfhydryl Compounds superoxide dismutase 2 Homo sapiens
2 Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs. Sulfhydryl Compounds superoxide dismutase 2 Homo sapiens
3 Manganese superoxide dismutase (Sod2) is one such gene whose expression levels have been shown to be elevated after exposure to the thiol compounds WR-1065 and N-acetyl-L-cysteine (NAC), resulting in an increase in radiation resistance. Sulfhydryl Compounds superoxide dismutase 2 Homo sapiens
4 This delayed radioprotective effect correlated with elevated Sod2 protein levels in wild-type SA-NH tumor cells but was not observed in SA-NH+mIkappaBalpha1 cells, indicating that interference with thiol-induced NFKB activation abrogates this delayed radioprotective effect. Sulfhydryl Compounds superoxide dismutase 2 Homo sapiens