Title : In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole.

Pub. Date : 2003

PMID : 15618748






2 Functional Relationships(s)
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1 ABT, SKF-525A, and ketoconazole showed different selectivity and had a wide range of Ki values for the drug oxidations catalyzed by human CYP enzymes. Proadifen cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 Therefore, we conclude that inhibitory studies designed to predict the contribution of CYP enzymes to the metabolism of certain compounds should be performed using multiple CYP inhibitors, such as ABT, SKF-525A, and ketoconazole. Proadifen cytochrome P450 family 4 subfamily F member 3 Homo sapiens