Title : Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}.

Pub. Date : 2005 Jan

PMID : 15616014






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Pan-protein kinase C (PKC) inhibitors significantly decreased high-glucose-induced IL-6 release. Glucose interleukin 6 Homo sapiens
2 Furthermore, the PKC-alpha/beta2 inhibitor decreased p38MAPK and the resulting high-glucose-induced IL-6 release. Glucose interleukin 6 Homo sapiens
3 Both antisense oligos to PKC-beta and -alpha as well as small interfering RNA (siRNA) to PKC-alpha and -beta resulted in significantly decreased high-glucose-induced IL-6 release. Glucose interleukin 6 Homo sapiens