Title : S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production.

Pub. Date : 2005 Jan

PMID : 15607954






1 Functional Relationships(s)
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1 Here we demonstrate that BACE (beta-secretase), as well as PS1, is regulated by methylation and that the reduction of folate and vitamin B12 in culture medium can cause a reduction of SAM levels with consequent increase in presenilin1 and BACE levels and with increase in A beta production. Folic Acid amyloid beta precursor protein Homo sapiens