Title : A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway.

Pub. Date : 2005 Jan 27

PMID : 15592521






1 Functional Relationships(s)
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1 Strikingly, CYR61 overexpression impaired the accumulation of wild-type p53 following Taxol exposure, while inhibition of alphavbeta3 or ERK1/ERK2 MAPK signalings completely restored Taxol-induced upregulation of p53. Paclitaxel mitogen-activated protein kinase 3 Homo sapiens