Pub. Date : 2004 Nov-Dec
PMID : 15591791
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vanadate stimulates monocytic differentiation activity of IL-6 by enhancing actin filament polymerization in HL-60 cells. | Vanadates | interleukin 6 | Homo sapiens |
| 2 | In the presence of vanadate (10 microM), a PTP inhibitor, IL-6 induced pronounced G0/G1 cell cycle arrest; this effect was associated with CD14+ monocytic differentiation as well as F-actin filament polymerization. | Vanadates | interleukin 6 | Homo sapiens |
| 3 | Furthermore, vanadate potentiated IL-6-signaling pathway by increasing the tyrosine phosphorylated levels of STAT3 (Tyr705), and Lyn. | Vanadates | interleukin 6 | Homo sapiens |
| 4 | Vanadate also cooperated with IL-6 to form a protein complex containing Lyn and an actin-associated protein, AFAP110. | Vanadates | interleukin 6 | Homo sapiens |
| 5 | In conclusion, inhibition of PTP by vanadate promotes hematopoietic differentiation activity of IL-6 through modulating multiple signalings, particularly actin filament polymerization. | Vanadates | interleukin 6 | Homo sapiens |