Title : High glucose decreases intracellular glutathione concentrations and upregulates inducible nitric oxide synthase gene expression in intestinal epithelial cells.

Pub. Date : 2004 Dec

PMID : 15591036






5 Functional Relationships(s)
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1 High glucose decreases intracellular glutathione concentrations and upregulates inducible nitric oxide synthase gene expression in intestinal epithelial cells. Glucose nitric oxide synthase 2 Homo sapiens
2 The aim of the study was to assess the effects of inflammatory cytokines and oxidative stress associated with increased glucose concentrations on inducible nitric oxide synthase (iNOS) promoter activity in intestinal epithelial cells. Glucose nitric oxide synthase 2 Homo sapiens
3 The aim of the study was to assess the effects of inflammatory cytokines and oxidative stress associated with increased glucose concentrations on inducible nitric oxide synthase (iNOS) promoter activity in intestinal epithelial cells. Glucose nitric oxide synthase 2 Homo sapiens
4 Upregulation of basal iNOS promoter activity was observed when cells were incubated in high glucose alone. Glucose nitric oxide synthase 2 Homo sapiens
5 In conclusion, iNOS promoter activity induced by high concentrations of glucose is mediated in part through intracellular GSH and NFkappaB. Glucose nitric oxide synthase 2 Homo sapiens