Title : Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.

Pub. Date : 2005 Feb 1

PMID : 15590702






1 Functional Relationships(s)
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1 Here, we report that polyglutamine-induced cell death was dramatically suppressed in flies lacking Dark, the fly homolog of human Apaf-1, a key regulator of apoptosis. polyglutamine apoptotic peptidase activating factor 1 Homo sapiens