Title : Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.

Pub. Date : 2005 Feb 1

PMID : 15590702






1 Functional Relationships(s)
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1 Apaf-1 also was found to colocalize with huntingtin-containing aggregates in a murine model and HD brain, suggesting a common role for Dark/Apaf-1 in polyglutamine pathogenesis in invertebrates, mice and man. polyglutamine dark Mus musculus