Pub. Date : 2005 Jan
PMID : 15569856
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In an endothelial cell line stably expressing human somatic ACE, ramiprilat increased COX-2 promoter activity, an effect not observed in ACE-deficient cells or cells expressing a nonphosphorylatable ACE mutant (S1270A). | ramiprilat | angiotensin I converting enzyme | Homo sapiens |
| 2 | The ramiprilat-induced, ACE-dependent increase in COX-2 expression and promoter activity (both 1.5- to 2-fold greater than control) was prevented by the inhibition of JNK. | ramiprilat | angiotensin I converting enzyme | Homo sapiens |
| 3 | Ramiprilat significantly enhanced the DNA binding activity of activator protein-1 in cells expressing ACE but not S1270A ACE. | ramiprilat | angiotensin I converting enzyme | Homo sapiens |