Pub. Date : 2004 Dec
PMID : 15569254
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Membranes prepared from cells expressing either SER-2 or SER-2A bind [3H]lysergic acid diethylamide (LSD) in the low nanomolar range and exhibit highest affinity for tyramine. | Tyramine | G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2 | Caenorhabditis elegans |
| 2 | Membranes prepared from cells expressing either SER-2 or SER-2A bind [3H]lysergic acid diethylamide (LSD) in the low nanomolar range and exhibit highest affinity for tyramine. | Tyramine | G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2 | Caenorhabditis elegans |
| 3 | Pertussis toxin treatment reduces affinity for both tyramine and octopamine, especially for octopamine in membranes from cells expressing SER-2, suggesting that the conformation of the mid-region of the third intracellular loop is dictated by G-protein interactions and is responsible for the differential tyramine/octopamine affinities of the two isoforms. | Tyramine | G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2 | Caenorhabditis elegans |
| 4 | Pertussis toxin treatment reduces affinity for both tyramine and octopamine, especially for octopamine in membranes from cells expressing SER-2, suggesting that the conformation of the mid-region of the third intracellular loop is dictated by G-protein interactions and is responsible for the differential tyramine/octopamine affinities of the two isoforms. | Tyramine | G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2 | Caenorhabditis elegans |
| 5 | Tyramine, but not octopamine, also elevates Ca2+ levels in cells expressing SER-2 and to a lesser extent SER-2A. | Tyramine | G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2 | Caenorhabditis elegans |