Title : Chemotherapy-induced cell death in primary cerebellar granule neurons but not in astrocytes: in vitro paradigm of differential neurotoxicity.

Pub. Date : 2004 Dec

PMID : 15569250






2 Functional Relationships(s)
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1 zVAD-fmk, a caspase inhibitor and brain-derived neurotrophic factor (BDNF), but not MK-801, a non-competitive NMDA receptor antagonist, significantly reduced vincristine- or topotecan-induced cell death. Topotecan brain-derived neurotrophic factor Rattus norvegicus
2 zVAD-fmk, a caspase inhibitor and brain-derived neurotrophic factor (BDNF), but not MK-801, a non-competitive NMDA receptor antagonist, significantly reduced vincristine- or topotecan-induced cell death. Topotecan brain-derived neurotrophic factor Rattus norvegicus