Title : Over-expression of human UREB1 in colorectal cancer: HECT domain of human UREB1 inhibits the activity of tumor suppressor p53 protein.

Pub. Date : 2005 Jan 7

PMID : 15567145






2 Functional Relationships(s)
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Protein Name
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1 The ubiquitination and destabilization of p53 is observed in cells treated with the protease inhibitor MG132, implying that the HECT domain of hUREB1 suppresses the transcriptional activity of p53 through a ubiquitin-dependent degradation pathway. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor protein p53 Homo sapiens
2 The ubiquitination and destabilization of p53 is observed in cells treated with the protease inhibitor MG132, implying that the HECT domain of hUREB1 suppresses the transcriptional activity of p53 through a ubiquitin-dependent degradation pathway. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor protein p53 Homo sapiens