Pub. Date : 2005 Mar 1
PMID : 15565650
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Vanadium induces apoptosis and modulates the expressions of metallothionein, Ki-67 nuclear antigen, and p53 during 2-acetylaminofluorene-induced rat liver preneoplasia. | Vanadium | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
2 | An increased immunopositivity of p53 protein (1.03 +/- 0.23%; P < 0.02) was found in vanadium-treated rat liver with an elevated apoptotic-labeling index (AI; P < 0.001) as documented by TUNEL assay. | Vanadium | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
3 | The results thus provide evidence for the first time in support of the potential role of vanadium on induction of p53 and apoptosis with concurrent suppression of MT and Ki-67 in order to have an understanding, in part, of the chemopreventive mechanism of this trace element in limiting neoplastic transformation in a defined model of experimental rat hepatocarcinogenesis. | Vanadium | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |