Title : Attenuation of nicotine's discriminative stimulus effects in rats and its locomotor activity effects in mice by serotonergic 5-HT2A/2C receptor agonists.

Pub. Date : 2005 May

PMID : 15565434






4 Functional Relationships(s)
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1 RATIONALE: Reports have indicated that administration of nicotine inhibits, while withdrawal of chronically administered nicotine augments effects of serotonergic 5HT2A/2C agonists. Nicotine 5-hydroxytryptamine receptor 2A Rattus norvegicus
2 OBJECTIVE: It was our objective to determine whether 5HT2A/2C agonists can modulate the discriminative stimulus effects of nicotine in rats or its locomotor activity effects in mice. Nicotine 5-hydroxytryptamine receptor 2A Rattus norvegicus
3 CONCLUSIONS: These results indicate that activation of serotonin 5HT2A/2C receptors can blunt the discriminative stimulus and locomotor activity effects of nicotine and presents the possibility that activation of these receptors might also be able to attenuate other effects of nicotine. Nicotine 5-hydroxytryptamine receptor 2A Rattus norvegicus
4 CONCLUSIONS: These results indicate that activation of serotonin 5HT2A/2C receptors can blunt the discriminative stimulus and locomotor activity effects of nicotine and presents the possibility that activation of these receptors might also be able to attenuate other effects of nicotine. Nicotine 5-hydroxytryptamine receptor 2A Rattus norvegicus