Title : Neuregulin-1beta induces neurite extension and arborization in cultured hippocampal neurons.

Pub. Date : 2004 Dec

PMID : 15555917






1 Functional Relationships(s)
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1 NRG-1beta effects on neurite extension and arborization are similar to, but not additive with, those of brain-derived neurotrophic factor and reflect direct NRG-1 action on hippocampal neurons as these cells express the NRG-1 receptors erbB2 and erbB4, the erbB-specific inhibitor PD158780 decreases NRG-1beta induced neurite outgrowth, and NRG-1beta stimulation induces p42/44 ERK phosphorylation. 6-(methylamino)pyrido(3,4-d)pyrimidine neuregulin 1 Homo sapiens