Title : Sulfonate ester hydroxamic acids as potent and selective inhibitors of TACE enzyme.

Pub. Date : 2003

PMID : 15553924






1 Functional Relationships(s)
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1 Replacement of the sulfonamide functionality with an isosteric sulfonate ester has resulted in a series of sulfonate ester hydroxamates, 2a-e, with excellent activity against TACE and excellent selectivity over MMP-1 and MMP-13. Sulfonamides matrix metallopeptidase 1 Homo sapiens