Pub. Date : 2005 Feb 11
PMID : 15550390
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Interestingly, IFN-gamma inhibited cAMP levels as well as its downstream signaling pathway as shown by the inhibition of adenosine-induced phosphorylation of cAMP response element-binding protein and protein kinase A activity. | Cyclic AMP | interferon gamma | Homo sapiens |
2 | Interestingly, IFN-gamma inhibited cAMP levels as well as its downstream signaling pathway as shown by the inhibition of adenosine-induced phosphorylation of cAMP response element-binding protein and protein kinase A activity. | Cyclic AMP | interferon gamma | Homo sapiens |
3 | Similar studies with forskolin, a direct activator of adenylate cyclase, also demonstrated inhibition of cAMP and its downstream response by IFN-gamma. | Cyclic AMP | interferon gamma | Homo sapiens |
4 | We propose that IFN-gamma may acutely affect global cAMP-mediated responses in the intestinal epithelia, thereby decreasing secretory responses, which may consequently aggravate inflammatory processes. | Cyclic AMP | interferon gamma | Homo sapiens |