Title : CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer.

Pub. Date : 2004 Nov 15

PMID : 15548719






3 Functional Relationships(s)
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Protein Name
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1 The enzyme products of CYP3A4 and CYP3A43 are involved in testosterone metabolism. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 The observation that CYP3A4 and CYP3A43 were associated with prostate cancer, are not in linkage equilibrium, and are both involved in testosterone metabolism, suggest that both CYP3A4*1B and CYP3A43*3 may influence the probability of having prostate cancer and disease severity. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 The observation that CYP3A4 and CYP3A43 were associated with prostate cancer, are not in linkage equilibrium, and are both involved in testosterone metabolism, suggest that both CYP3A4*1B and CYP3A43*3 may influence the probability of having prostate cancer and disease severity. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens