Pub. Date : 2004 Dec
PMID : 15547704
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Functional assays using chemical inhibitors demonstrated that the phosphorylation of ERK was mediated by reactive oxygen species in an Raf-1-independent manner and required the activation of caspase-3. | Reactive Oxygen Species | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Thus, our data suggest that CDDP mediates its apoptosis-inducing effect on the human malignant testicular germ cells, at least partially, through activation of the MEK-ERK signaling pathway in a ROS-dependent, Raf-1-independent manner. | Reactive Oxygen Species | mitogen-activated protein kinase 1 | Homo sapiens |