Pub. Date : 2004 Nov
PMID : 15535897
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To explore the protective effect of morphine and its mechanism on acute myocardial ischemia/reperfusion (AMIR) injury in rats, by the method of detecting calcitonin gene-related peptide (CGRP) and endothelin-1 (ET-1) levels, as well as myocardial infarct size. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 2 | OBJECTIVE: To explore the protective effect of morphine and its mechanism on acute myocardial ischemia/reperfusion (AMIR) injury in rats, by the method of detecting calcitonin gene-related peptide (CGRP) and endothelin-1 (ET-1) levels, as well as myocardial infarct size. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 3 | Plasma ET-1 and CK-MB levels in morphine preconditioning group in AMIR at 45 hours of reperfusion were decreased significantly as compared with that in the same group in AMI at 10 minutes, and myocardial infarct size decreased significantly (all P<0.01), while, plasma CGRP levels were markedly increased. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 4 | CONCLUSION: Intravenous morphine has protective effects on AMI by increased plasma CGRP level, decreased plasma ET-1 level, and reduced myocardial infarct size. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |