Pub. Date : 2005
PMID : 15533631
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A-Raf, Akt, PKC, MEK, ERK, and transcription factors AP-1, NF-kappaB, and CREB are targets of both estrogen and ROS. | Reactive Oxygen Species | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | We provide four lines of evidence in support of our hypothesis that estrogen-induced mitochondrial ROS stimulate redox sensor kinase A-Raf, Akt or PKC, which, in turn, activate transcription factors NF-kappaB, CREB, or AP-1 via the MEK/ERK pathway. | Reactive Oxygen Species | mitogen-activated protein kinase 1 | Homo sapiens |