Title : Endothelin-1 decreases endothelial NOS expression and activity through ETA receptor-mediated generation of hydrogen peroxide.

Pub. Date : 2005 Mar

PMID : 15531748






1 Functional Relationships(s)
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1 Thus the objective of this study was to determine whether there was a feedback mechanism between the ET-1-mediated increase in ROS in fetal PASMC (FPASMC) and a decrease in eNOS gene expression in fetal pulmonary arterial endothelial cells (FPAEC). pasmc endothelin 1 Homo sapiens