Pub. Date : 2005 Mar
PMID : 15531748
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Endothelin-1 decreases endothelial NOS expression and activity through ETA receptor-mediated generation of hydrogen peroxide. | Hydrogen Peroxide | nitric oxide synthase 3 | Homo sapiens |
| 2 | In FPAEC in monoculture treated with 0-100 microM H2O2, 12 microM had no effect on eNOS promoter activity, but it increased eNOS protein levels by 50%. | Hydrogen Peroxide | nitric oxide synthase 3 | Homo sapiens |
| 3 | However, at 100 microM, H2O2 decreased eNOS promoter activity and protein levels in FPAEC by 79 and 40%, respectively. | Hydrogen Peroxide | nitric oxide synthase 3 | Homo sapiens |
| 4 | These data suggest a role for smooth muscle cell-derived H2O2 in ET-1-mediated downregulation of eNOS expression in children born with PPHN. | Hydrogen Peroxide | nitric oxide synthase 3 | Homo sapiens |