Pub. Date : 2004 Dec 10
PMID : 15530425
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Therefore, our study concentrates on the effect of the ACE-inhibitor ramiprilat on chemokine release, AngII receptor (ATR) expression, and NF-kappaB activity in monocytes stimulated with AngII. | ramiprilat | angiotensinogen | Homo sapiens |
| 2 | Ramiprilat dose-dependently suppressed AngII-induced upregulation of IL-8 and MCP-1. | ramiprilat | angiotensinogen | Homo sapiens |
| 3 | The suppressive effect of ramiprilat on AngII-induced chemokine production and release was in part caused by downregulation of NF-kappaB, but more by a selective and highly significant reduced expression of AT1 receptors as shown in monocytes and endothelial cells. | ramiprilat | angiotensinogen | Homo sapiens |
| 4 | In addition, ramiprilat downregulated NF-kappaB activity and thereby reduced the AngII-induced release of IL-8 and MCP-1 in monocytes. | ramiprilat | angiotensinogen | Homo sapiens |