Title : Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion.

Pub. Date : 2005 Mar 1

PMID : 15528316






5 Functional Relationships(s)
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1 Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion. Etoposide lysine methyltransferase 2A Homo sapiens
2 Rearrangements involving the MLL gene on chromosome band 11q23 are a hallmark of therapy-related acute myeloid leukemias following treatment with topoisomerase II poisons including etoposide. Etoposide lysine methyltransferase 2A Homo sapiens
3 Repair of etoposide-stabilized DNA topoisomerase II covalent complexes may initiate MLL rearrangements observed in patients. Etoposide lysine methyltransferase 2A Homo sapiens
4 We used a culture system of primary human hematopoietic CD34+ cells and inverse polymerase chain reaction to characterize the spectrum of stable genomic rearrangements promoted by etoposide exposure originating within an MLL translocation hotspot in therapy-related leukemia. Etoposide lysine methyltransferase 2A Homo sapiens
5 Thus, etoposide promotes specific rearrangements of MLL consistent with the full spectrum of oncogenic events identified in leukemic samples. Etoposide lysine methyltransferase 2A Homo sapiens