Title : Bcl-2 family proteins regulate mitochondrial reactive oxygen production and protect against oxidative stress.

Pub. Date : 2004 Dec 1

PMID : 15528043






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Chronic exposure of cells to low levels of the mitochondrial uncoupler carbonyl cyanide 4-(triflouromethoxy)phenylhydrazone reduced the rate of H(2)O(2) production by Bcl-xL overexpressing cells, resulting in a decreased ability to remove exogenous H(2)O(2) and enhanced cell death under conditions of acute oxidative stress. Hydrogen Peroxide BCL2 like 1 Homo sapiens
2 Chronic exposure of cells to low levels of the mitochondrial uncoupler carbonyl cyanide 4-(triflouromethoxy)phenylhydrazone reduced the rate of H(2)O(2) production by Bcl-xL overexpressing cells, resulting in a decreased ability to remove exogenous H(2)O(2) and enhanced cell death under conditions of acute oxidative stress. Hydrogen Peroxide BCL2 like 1 Homo sapiens
3 Our results indicate that chronic and mild elevations in H(2)O(2) release from Bcl-2, Bcl-xL, and Mcl-1 overexpressing mitochondria lead to enhanced cellular antioxidant defense and protection against death caused by acute oxidative stress. Hydrogen Peroxide BCL2 like 1 Homo sapiens