Title : Homocysteine induces production of monocyte chemoattractant protein-1 and interleukin-8 in cultured human whole blood.

Pub. Date : 2004 Nov

PMID : 15525462






7 Functional Relationships(s)
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1 Homocysteine induces production of monocyte chemoattractant protein-1 and interleukin-8 in cultured human whole blood. Homocysteine C-C motif chemokine ligand 2 Homo sapiens
2 AIM: To investigate whether increased plasma L-homocysteine (Hcy) level could promote monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured whole blood. Homocysteine C-C motif chemokine ligand 2 Homo sapiens
3 AIM: To investigate whether increased plasma L-homocysteine (Hcy) level could promote monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured whole blood. Homocysteine C-C motif chemokine ligand 2 Homo sapiens
4 AIM: To investigate whether increased plasma L-homocysteine (Hcy) level could promote monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured whole blood. Homocysteine C-C motif chemokine ligand 2 Homo sapiens
5 AIM: To investigate whether increased plasma L-homocysteine (Hcy) level could promote monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured whole blood. Homocysteine C-C motif chemokine ligand 2 Homo sapiens
6 radicals, play extremely important role in the Hcy-induced MCP-1 and IL-8 production. Homocysteine C-C motif chemokine ligand 2 Homo sapiens
7 CONCLUSION: Increased Hcy level in plasma (hyperhomocysteinemia) induced MCP-1 and IL-8 secretion in cultured human whole blood, especially in monocytes via oxidative stress mechanism. Homocysteine C-C motif chemokine ligand 2 Homo sapiens