Pub. Date : 2004 Dec 15
PMID : 15523637
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we demonstrate that PGJ2 enhances COX-2 gene expression without elevating COX-1 levels in neuronal cells. | 9-deoxy-delta-9-prostaglandin D2 | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | PGJ2 also increased PGE2 production, establishing that the de novo synthesized COX-2 is enzymatically active. | 9-deoxy-delta-9-prostaglandin D2 | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | However, the selective PPARgamma agonist ciglitazone failed to up-regulate COX-2, indicating that the PGJ2 effect on COX-2 is PPARgamma independent. | 9-deoxy-delta-9-prostaglandin D2 | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | The proinflammatory cytokine may mediate COX-2 up-regulation by PGJ2 through p38MAPK and not JNK activation, in that only an inhibitor of the former prevented the COX-2 increase. | 9-deoxy-delta-9-prostaglandin D2 | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 5 | The proinflammatory cytokine may mediate COX-2 up-regulation by PGJ2 through p38MAPK and not JNK activation, in that only an inhibitor of the former prevented the COX-2 increase. | 9-deoxy-delta-9-prostaglandin D2 | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 6 | Collectively, our findings suggest that proinflammatory conditions that lead to COX-2 up-regulation and the concomitant production of PGJ2 initiate a mechanism of self-destruction through an autotoxic loop between PGJ2 and COX-2 that may exacerbate neurodegeneration beyond a point of no return. | 9-deoxy-delta-9-prostaglandin D2 | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 7 | Collectively, our findings suggest that proinflammatory conditions that lead to COX-2 up-regulation and the concomitant production of PGJ2 initiate a mechanism of self-destruction through an autotoxic loop between PGJ2 and COX-2 that may exacerbate neurodegeneration beyond a point of no return. | 9-deoxy-delta-9-prostaglandin D2 | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |