Title : Ceramide promotes apoptosis in lung cancer-derived A549 cells by a mechanism involving c-Jun NH2-terminal kinase.

Pub. Date : 2004 Nov 1

PMID : 15520191






8 Functional Relationships(s)
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1 Ceramide is known to potently activate a number of stress-regulated enzymes, including the c-Jun NH(2)-terminal kinase (JNK). Ceramides mitogen-activated protein kinase 8 Homo sapiens
2 Ceramide is known to potently activate a number of stress-regulated enzymes, including the c-Jun NH(2)-terminal kinase (JNK). Ceramides mitogen-activated protein kinase 8 Homo sapiens
3 Here, we report that ceramide promotes apoptosis in A549 cells by a mechanism involving JNK. Ceramides mitogen-activated protein kinase 8 Homo sapiens
4 The JNK inhibitor SP600125 proved effective at protecting cells from the lethal effects of ceramide. Ceramides mitogen-activated protein kinase 8 Homo sapiens
5 Ceramide was found to inhibit c-Jun phosphorylation, suggesting that JNK-mediated phosphorylation of c-Jun is not likely involved in ceramide-induced apoptosis. Ceramides mitogen-activated protein kinase 8 Homo sapiens
6 On the other hand, ceramide promoted phosphorylation of Bim and induced translocation of active JNK from the nucleus to the cytoplasm and mitochondrial fraction. Ceramides mitogen-activated protein kinase 8 Homo sapiens
7 Ceramide-mediated changes in localization of JNK were consistent with the observed changes in phosphorylation status of c-Jun and Bim. Ceramides mitogen-activated protein kinase 8 Homo sapiens
8 These results suggest that JNK may participate in ceramide-induced apoptosis in A549 cells by a mechanism involving Bim. Ceramides mitogen-activated protein kinase 8 Homo sapiens