Pub. Date : 2004 Nov 1
PMID : 15520191
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ceramide is known to potently activate a number of stress-regulated enzymes, including the c-Jun NH(2)-terminal kinase (JNK). | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Ceramide is known to potently activate a number of stress-regulated enzymes, including the c-Jun NH(2)-terminal kinase (JNK). | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Here, we report that ceramide promotes apoptosis in A549 cells by a mechanism involving JNK. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | The JNK inhibitor SP600125 proved effective at protecting cells from the lethal effects of ceramide. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Ceramide was found to inhibit c-Jun phosphorylation, suggesting that JNK-mediated phosphorylation of c-Jun is not likely involved in ceramide-induced apoptosis. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | On the other hand, ceramide promoted phosphorylation of Bim and induced translocation of active JNK from the nucleus to the cytoplasm and mitochondrial fraction. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | Ceramide-mediated changes in localization of JNK were consistent with the observed changes in phosphorylation status of c-Jun and Bim. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 8 | These results suggest that JNK may participate in ceramide-induced apoptosis in A549 cells by a mechanism involving Bim. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |