Title : Cyclooxygenase-2 gene induction causes CDDP resistance in colon cancer cell line, HCT-15.

Pub. Date : 2004 Sep-Oct

PMID : 15517878






1 Functional Relationships(s)
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1 In conclusion, COX-2 overexpression induced increased MRP-1 expression in a colon cancer cell line, TR-5, resulting in chemoresistance to CDDP that was approximately triple the level of chemoresistance observed in the original HCT-15 cells line, as measured by calculation of the IC50. Cisplatin ATP binding cassette subfamily C member 1 Homo sapiens