Title : Tumor-derived prostaglandin E2 and transforming growth factor-beta stimulate endothelial cell motility through inhibition of protein phosphatase-2A and involvement of PTEN and phosphatidylinositide 3-kinase.

Pub. Date : 2004

PMID : 15516833






2 Functional Relationships(s)
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1 Concurrent with the decline in PP-2A activity as a result of exposure to PGE2/TGFbeta was a loss of PP-2A co-precipitation with the inositol phosphatase PTEN and an increase in the PTEN serine phosphorylation level. Dinoprostone transforming growth factor beta 1 Homo sapiens
2 These studies showed that the increased endothelial cell motility that resulted from PGE2/TGFbeta inhibition of PP-2A was dependent on PI3K. Dinoprostone transforming growth factor beta 1 Homo sapiens