Pub. Date : 1992 Apr 1
PMID : 1551112
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of p34cdc2 kinase activation, p34cdc2 tyrosine dephosphorylation, and mitotic progression in Chinese hamster ovary cells exposed to etoposide. | Etoposide | cyclin dependent kinase 1 | Homo sapiens |
| 2 | Inhibition of p34cdc2 kinase activation, p34cdc2 tyrosine dephosphorylation, and mitotic progression in Chinese hamster ovary cells exposed to etoposide. | Etoposide | cyclin dependent kinase 1 | Homo sapiens |
| 3 | p34cdc2 kinase, an enzyme essential for mitosis in mammalian cells, may play a role in etoposide-induced G2 phase arrest of Chinese hamster ovary cells. | Etoposide | cyclin dependent kinase 1 | Homo sapiens |
| 4 | In this study, etoposide is shown to cause inhibition of a specific p34cdc2 kinase activation pathway, that of tyrosine dephosphorylation. | Etoposide | cyclin dependent kinase 1 | Homo sapiens |
| 5 | Exposure of asynchronously dividing cells to etoposide caused a simultaneous rapid decline of both mitotic index and p34cdc2 kinase activity, suggesting that the kinase was not activated and that the arrest point was in late G2 phase. | Etoposide | cyclin dependent kinase 1 | Homo sapiens |
| 6 | A 1-h exposure to etoposide during early G2 phase inhibited p34cdc2 kinase activation, its shift in electrophoretic mobility, and its tyrosine dephosphorylation, all of which correlated with a delay in mitotic progression. | Etoposide | cyclin dependent kinase 1 | Homo sapiens |