Pub. Date : 2004 Dec
PMID : 15505117
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We investigated the involvement of the PI3-K/Akt pathway in the relaxation responses to acetylcholine (ACh) and clonidine in a new type 2 diabetic model (streptozotocin plus nicotinamide-induced diabetic mice). | Clonidine | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | In control mice, the clonidine-induced and insulin-induced relaxations were each abolished by LY294002 and by Wortmannin (inhibitors of PI3-K), and also by Akt-inhibitor treatment. | Clonidine | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | The clonidine-induced Ser-473 phosphorylation of Akt through PI3-K was significantly decreased in our model; however, that induced by ACh was not. | Clonidine | thymoma viral proto-oncogene 1 | Mus musculus |