Title : Impact of the cyclooxygenase system on doxorubicin-induced functional multidrug resistance 1 overexpression and doxorubicin sensitivity in acute myeloid leukemic HL-60 cells.

Pub. Date : 2005 Jan

PMID : 15501994






1 Functional Relationships(s)
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1 In conclusion, the cyclooxygenase system, especially the cyclooxygenase-2 isoform, might be involved in regulating doxorubicin-induced MDR1 overexpression in AML cells, with PGE(2) seeming to be a mediating factor. Prostaglandins E ATP binding cassette subfamily B member 1 Homo sapiens