Pub. Date : 2004 Jun
PMID : 15499994
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Physical interactions have been identified between the carbonic anhydrase isoform, CAII, and the erythrocyte membrane Cl- /HCO3(-) anion exchanger, AE1, mediated by an acidic motif in the AE1 C-terminus. | Bicarbonates | carbonic anhydrase 2 | Homo sapiens |
| 2 | We have found that the presence of CAII attached to AE1 accelerates AE1 HCO3(-) transport activity, as AE1 moves bicarbonate either into or out of the cell. | Bicarbonates | carbonic anhydrase 2 | Homo sapiens |
| 3 | In efflux mode the presence of CAII attached to AE1 will increase the local concentration of bicarbonate at the AE1 transport site. | Bicarbonates | carbonic anhydrase 2 | Homo sapiens |
| 4 | As bicarbonate is transported into the cell by AE1, the presence of CAII on the cytosolic surface accelerates transport by consumption of bicarbonate, thereby maximizing the transmembrane bicarbonate concentration gradient experienced by the AE1 molecule. | Bicarbonates | carbonic anhydrase 2 | Homo sapiens |
| 5 | As bicarbonate is transported into the cell by AE1, the presence of CAII on the cytosolic surface accelerates transport by consumption of bicarbonate, thereby maximizing the transmembrane bicarbonate concentration gradient experienced by the AE1 molecule. | Bicarbonates | carbonic anhydrase 2 | Homo sapiens |
| 6 | As bicarbonate is transported into the cell by AE1, the presence of CAII on the cytosolic surface accelerates transport by consumption of bicarbonate, thereby maximizing the transmembrane bicarbonate concentration gradient experienced by the AE1 molecule. | Bicarbonates | carbonic anhydrase 2 | Homo sapiens |
| 7 | Functional and physical interactions also occur between CAII and Na+/HCO3(-) co-transporter isoforms NBC1 and NBC3. | Bicarbonates | carbonic anhydrase 2 | Homo sapiens |
| 8 | All examined bicarbonate transport proteins, except the DRA (SLC26A3) Cl-/HCO3(-) exchange protein, have a consensus CAII binding site in their cytoplasmic C-terminus. | Bicarbonates | carbonic anhydrase 2 | Homo sapiens |
| 9 | All examined bicarbonate transport proteins, except the DRA (SLC26A3) Cl-/HCO3(-) exchange protein, have a consensus CAII binding site in their cytoplasmic C-terminus. | Bicarbonates | carbonic anhydrase 2 | Homo sapiens |
| 10 | In summary, bicarbonate transporters directly interact with the CAII and CAIV carbonic anhydrases to increase the transmembrane bicarbonate flux. | Bicarbonates | carbonic anhydrase 2 | Homo sapiens |