Title : Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity.

Pub. Date : 2004 Jun

PMID : 15499183






2 Functional Relationships(s)
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1 More recently, it has been reported that megalin, a giant endocytic receptor abundantly expressed at the apical membrane of renal proximal tubules, plays an important role in binding and endocytosis of aminoglycosides in the proximal tubular cells. Aminoglycosides LDL receptor related protein 2 Homo sapiens
2 In this review, we summarize recent advances in the understandings of the molecular mechanisms responsible for renal accumulation of aminoglycosides, especially megalin-mediated endocytosis. Aminoglycosides LDL receptor related protein 2 Homo sapiens