Pub. Date : 2004 Apr
PMID : 15499178
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, the correlation coefficients of CYP3A5 contents with the rates of diltiazem N-demethylation, midazolam 1"-hydroxylation and testosterone 6beta- hydroxylation were higher than those of CYP3A4, although the value of CYP3A5 with the midazolam 4-hydroxylation rate was similar to that of CYP3A4. | Diltiazem | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | The apparent V(max)/K(m) values for recombinant CYP3A5 indicated the greater contributions to diltiazem N-demethylation and midazolam 1"-hydroxylation as compared with CYP3A4. | Diltiazem | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 3 | These results suggest that polymorphic CYP3A5 contributes markedly to the drug oxidations, particularly diltiazem N-demethylation, midazolam 1"- hydroxylation and testosterone 6beta-hydroxylation by liver microsomes from Japanese subjects. | Diltiazem | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |