Pub. Date : 2004 Dec 1
PMID : 15498514
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | Reactivators (oximes) of inhibited AChE are a mainstay of treatment, however, the commercially available compounds, obidoxime and pralidoxime, are considered to be rather ineffective against various nerve agents. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | However, the various interactions between AChE, OP and oximes can be investigated with human AChE which enables the direct assessment of oxime potency, thus excluding species differences. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | However, the various interactions between AChE, OP and oximes can be investigated with human AChE which enables the direct assessment of oxime potency, thus excluding species differences. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | The inhibitory potency of OPs, reactivating potency of oximes and spontaneous reactivation and aging were strongly affected by the structural characteristics of the OPs and of the phosphyl-AChE-complex. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 6 | AChE inhibited by various phosphoramidates was mostly resistant towards reactivation by oximes while phosphonylated AChE was easily reactivated. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |