Pub. Date : 2004 Nov
PMID : 15496645
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Employing primary cultures of human hepatocytes, they compared the CYP3A4 inductive effects of efavirenz (1-10 microM) to rifampin (10 microM) and phenobarbital (2 mM). | efavirenz | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | The authors observed that efavirenz caused a concentration-dependent CYP3A4 induction and hPXR activation. | efavirenz | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Based on the CYP3A4 activity assay, the average magnitude of induction by efavirenz (5-10 microM) was approximately 3- to 4-fold. | efavirenz | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |