Pub. Date : 2005 Mar
PMID : 15494548
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Unique binding interactions of valdecoxib with COX-2 translate into a fast rate of inactivation of COX-2 (110,000 M/s compared with 7000 M/s for rofecoxib and 80 M/s for etoricoxib). | rofecoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | The overall saturation binding affinity for COX-2 of valdecoxib is 2.6 nM (compared with 1.6 nM for celecoxib, 51 nM for rofecoxib, and 260 nM for etoricoxib), with a slow off-rate (t(1/2) approximately 98 min). | rofecoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |