Title : Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase.

Pub. Date : 2004 Sep

PMID : 15489061






2 Functional Relationships(s)
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1 Both cell lines displayed a higher DNA-binding activity of p53 and HIF-1 72 h after H2O2 exposure. Hydrogen Peroxide tumor protein p53 Homo sapiens
2 Our results indicate that similar mechanisms involving p21(WAF-1) and probably p53 are at work in BJ and hTERT-BJ1 HDFs under H2O2-induced SIPS, suggesting that generalized DNA damage rather than telomere length/telomerase plays a crucial role in H2O2induced SIPS. Hydrogen Peroxide tumor protein p53 Homo sapiens