Title : High-content screening with siRNA optimizes a cell biological approach to drug discovery: defining the role of P53 activation in the cellular response to anticancer drugs.

Pub. Date : 2004 Oct

PMID : 15475475






3 Functional Relationships(s)
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Protein Name
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1 Camptothecin activated p53 in A549 lung carcinoma cells pretreated with scrambled siRNA, exhibited concentration-dependent cell cycle blocks, and induced moderate microtubule stabilization. Camptothecin tumor protein p53 Homo sapiens
2 Knockdown of camptothecin-induced p53 protein expression with p53 siRNA inhibited the G1/S blocking activity of the drug and diminished its microtubule-stabilizing activity. Camptothecin tumor protein p53 Homo sapiens
3 Knockdown of camptothecin-induced p53 protein expression with p53 siRNA inhibited the G1/S blocking activity of the drug and diminished its microtubule-stabilizing activity. Camptothecin tumor protein p53 Homo sapiens