Title : Role of the retinal hydrogen bond network in rhodopsin Schiff base stability and hydrolysis.

Pub. Date : 2004 Dec 31

PMID : 15475355






1 Functional Relationships(s)
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1 We find deuterium affects the hydrolysis process in wild-type rhodopsin, exhibiting a specific isotope effect of approximately 2.5, and proton inventory studies indicate that multiple proton transfer events occur during the process of Schiff base hydrolysis for both dark state and MII forms. Deuterium rhodopsin Homo sapiens