Title : Extracellular receptor kinase and cAMP response element binding protein activation in the neonatal rat heart after perinatal cocaine exposure.

Pub. Date : 2004 Dec

PMID : 15470197






3 Functional Relationships(s)
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1 Prenatal exposure to cocaine has been shown to induce an increase in the myocardial expression and activation of the cAMP response binding protein (CREB), a transcriptional factor that has been shown to regulate gene expression. Cocaine cAMP responsive element binding protein 1 Rattus norvegicus
2 Prenatal exposure to cocaine has been shown to induce an increase in the myocardial expression and activation of the cAMP response binding protein (CREB), a transcriptional factor that has been shown to regulate gene expression. Cocaine cAMP responsive element binding protein 1 Rattus norvegicus
3 Our results thus illustrate that the ERK-RSK pathway was active in the postnatal rat heart at 1 and 7 d of age and that this pathway may mediate the increase in myocardial CREB activation after perinatal cocaine exposure in the day 7 hearts. Cocaine cAMP responsive element binding protein 1 Rattus norvegicus